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Moreover, these data-driven strategies facilitate dynamic, personalized care by continuously monitoring patient responses in real-time and promptly adjusting treatment plans as needed [198, 209]

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Additionally, utilizing controlled delivery systems, like nanoparticles or exosome-based platforms, can help ensure that therapeutic agents are specifically delivered to the tumor microenvironment, reducing systemic exposure and toxicity

Let us remind that measures the strength of the vertical flux of nutrients, being a specificity of the melanoma geometry in the epidermis

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